1001 - Document - Cover Page link:presentationLink link:definitionLink link:calculationLink 1002 - Statement - Condensed Balance Sheets link:presentationLink link:definitionLink link:calculationLink 1003 - Statement - Condensed Balance Sheets (Parenthetical) link:presentationLink link:definitionLink link:calculationLink 1004 - Statement - Condensed Statements of Operations and Comprehensive Income (Loss) link:presentationLink link:definitionLink link:calculationLink 1005 - Statement - Condensed Statements of Cash Flows link:presentationLink link:definitionLink link:calculationLink 1006 - Statement - Condensed Statements of Stockholders' Equity link:presentationLink link:definitionLink link:calculationLink 1007 - Disclosure - Nature of operations link:presentationLink link:definitionLink link:calculationLink 1008 - Disclosure - Summary of significant accounting policies link:presentationLink link:definitionLink link:calculationLink 1009 - Disclosure - Cash, cash equivalents, and restricted cash link:presentationLink link:definitionLink link:calculationLink 1010 - Disclosure - Investments link:presentationLink link:definitionLink link:calculationLink 1011 - Disclosure - Property and equipment, net link:presentationLink link:definitionLink link:calculationLink 1012 - Disclosure - Intangible asset, net link:presentationLink link:definitionLink link:calculationLink 1013 - Disclosure - Accounts payable and other liabilities link:presentationLink link:definitionLink link:calculationLink 1014 - Disclosure - Leases link:presentationLink link:definitionLink link:calculationLink 1015 - Disclosure - Equity link:presentationLink link:definitionLink link:calculationLink 1016 - Disclosure - Net loss per share link:presentationLink link:definitionLink link:calculationLink 1017 - Disclosure - Income taxes link:presentationLink link:definitionLink link:calculationLink 1018 - Disclosure - License and patent agreements link:presentationLink link:definitionLink link:calculationLink 1019 - Disclosure - 401(k) plan link:presentationLink link:definitionLink link:calculationLink 1020 - Disclosure - Restructurings and impairment charges link:presentationLink link:definitionLink link:calculationLink 1021 - Disclosure - Subsequent Events link:presentationLink link:definitionLink link:calculationLink 1022 - Disclosure - Summary of significant accounting policies (Policies) link:presentationLink link:definitionLink link:calculationLink 1023 - Disclosure - Summary of significant accounting policies (Tables) link:presentationLink link:definitionLink link:calculationLink 1024 - Disclosure - Cash, cash equivalents, and restricted cash (Tables) link:presentationLink link:definitionLink link:calculationLink 1025 - Disclosure - Investments (Tables) link:presentationLink link:definitionLink link:calculationLink 1026 - Disclosure - Property and equipment, net (Tables) link:presentationLink link:definitionLink link:calculationLink 1027 - Disclosure - Intangible asset, net (Tables) link:presentationLink link:definitionLink link:calculationLink 1028 - Disclosure - Accounts payable and other liabilities (Tables) link:presentationLink link:definitionLink link:calculationLink 1029 - Disclosure - Leases (Tables) link:presentationLink link:definitionLink link:calculationLink 1030 - Disclosure - Stockholders' equity (Tables) link:presentationLink link:definitionLink link:calculationLink 1031 - Disclosure - Net loss per common stock (Tables) link:presentationLink link:definitionLink link:calculationLink 1032 - Disclosure - Income taxes (Tables) link:presentationLink link:definitionLink link:calculationLink 1033 - Disclosure - Workforce reduction (Tables) link:presentationLink link:definitionLink link:calculationLink 1034 - Disclosure - Summary of significant accounting policies - Additional Information (Details) link:presentationLink link:definitionLink link:calculationLink 1035 - Disclosure - Summary of significant accounting policies - Cash and cash equivalents and restricted cash (Details) link:presentationLink link:definitionLink link:calculationLink 1036 - Disclosure - Summary of significant accounting policies - Fair Value (Details) link:presentationLink link:definitionLink link:calculationLink 1037 - Disclosure - Cash, cash equivalents, and restricted cash - Schedule of Cash, Cash Equivalents, and Restricted Cash (Details) link:presentationLink link:definitionLink link:calculationLink 1038 - Disclosure - Cash, cash equivalents, and restricted cash - Additional Information (Details) link:presentationLink link:definitionLink link:calculationLink 1039 - Disclosure - Investments (Details) link:presentationLink link:definitionLink link:calculationLink 1040 - Disclosure - Property and equipment, net - Schedule of Property and Equipment (Details) link:presentationLink link:definitionLink link:calculationLink 1041 - Disclosure - Property and equipment, net - Additional Information (Details) link:presentationLink link:definitionLink link:calculationLink 1042 - Disclosure - Intangible asset, net - Summary of Intangible Asset (Details) link:presentationLink link:definitionLink link:calculationLink 1043 - Disclosure - Accounts payable and other liabilities - Schedule of Accounts Payable and Other Liabilities (Details) link:presentationLink link:definitionLink link:calculationLink 1044 - Disclosure - Leases - Additional Information (Details) link:presentationLink link:definitionLink link:calculationLink 1045 - Disclosure - Leases - Schedule of Components of Lease Expense (Details) link:presentationLink link:definitionLink link:calculationLink 1046 - Disclosure - Leases - Supplemental Balance Sheet Information Related to Leases (Details) link:presentationLink link:definitionLink link:calculationLink 1047 - Disclosure - Leases - Supplemental Cash flow Information Related to Leases (Details) link:presentationLink link:definitionLink link:calculationLink 1048 - Disclosure - Leases - Schedule of Company's Operating and Finance Lease Liabilities (Details) link:presentationLink link:definitionLink link:calculationLink 1049 - Disclosure - Equity - Additional Information (Details) link:presentationLink link:definitionLink link:calculationLink 1050 - Disclosure - Equity - Schedule of Stock Option Activity (Details) link:presentationLink link:definitionLink link:calculationLink 1051 - Disclosure - Equity - Schedule of Weighted Average Assumptions (Details) link:presentationLink link:definitionLink link:calculationLink 1052 - Disclosure - Equity - Schedule of RSU Activity (Details) link:presentationLink link:definitionLink link:calculationLink 1053 - Disclosure - Equity - Summary of Stock-based Compensation Expense (Details) link:presentationLink link:definitionLink link:calculationLink 1054 - Disclosure - Net loss per share - Schedule of Securities Excluded From Computation of Earnings Per Share (Details) link:presentationLink link:definitionLink link:calculationLink 1055 - Disclosure - Income taxes - Schedule of Income Tax Recovery (Details) link:presentationLink link:definitionLink link:calculationLink 1056 - Disclosure - Income taxes - Schedule of Net (Loss) Income Before Taxes (Details) link:presentationLink link:definitionLink link:calculationLink 1057 - Disclosure - Income taxes - Components of Deferred Income Tax Assets (Details) link:presentationLink link:definitionLink link:calculationLink 1058 - Disclosure - Income taxes - Additional Information (Details) link:presentationLink link:definitionLink link:calculationLink 1059 - Disclosure - License and patent agreements - Additional Information (Details) link:presentationLink link:definitionLink link:calculationLink 1060 - Disclosure - Restructurings and impairment charges (Details) link:presentationLink link:definitionLink link:calculationLink 1061 - Disclosure - Subsequent Events (Details) link:presentationLink link:definitionLink link:calculationLink 1062 - Statement - Leases - Schedule of Company's Operating and Finance Lease Liabilities (Details) Alternate 1 link:presentationLink link:definitionLink link:calculationLink